Manufacturing of amorphous pharmaceutical formulations can be complex and costly. KinetiSol is an elegantly simple manufacturing technology capable of high-throughput production of amorphous systems.

KinetiSol is based on a commercial plastics compounding process and was developed by DisperSol into a cGMP-compliant pharmaceutical technology. The KinetiSol pharmaceutical manufacturing process can be run from kiloton-commercial scale down to sub-10 gram batch sizes to accommodate the material-sparing needs of early drug development.

Process Attributes

– Non-solvent process

– No external heat applied

– Processing times typically <20 s

– Elevated temperatures for typically <5 s

– Processing of high viscosity materials

– cGMP compliant

– Scale-up established

Fusion-Based Process

– Utilizes frictional and shear energies

– Rapid transition to molten state

– Simultaneous high-intensity mixing

– Real-time temperature monitoring

– Discharge at temperature set-point

Processing Scale

– Lab-scale with <10 g per batch

– Commercial-scale 40 kg/hr/unit

WHY USE KINETISOL ?

KinetiSol Fits In-Line with Existing Manufacturing Operations
  • Solve formulating challenges no other technology can
  • Create patent-protected compositions no other technology can
  • Make higher-performing products