DisperSol News
July 2021
DisperSol Technologies Promotes Chris Brough to Chief Technology Officer
DisperSol Technologies Promotes Dave Miller to Chief Scientific Officer
September 2020
DisperSol Technologies Names David Snyder as Chief Financial Officer
April 2018
November 2017
DisperSol Technologies Announces New R&D Data to Be Presented at 2017 Annual Meeting of AAPS
November 2016
DisperSol Names Dr. Edward M. Rudnic as Chief Executive Officer, RCT Leads $12 Million Funding Round
February 2015
KinetiSol® Publications
Ellenberger, D.J., Dave A. Miller, Sandra U. Kucera, Robert O. Williams III. “Generation of a Weakly Acidic Amorphous Solid Dispersion of the Weak Base Ritonavir with Equivalent In Vitro and In Vivo Performance to Norvir Tablet.” AAPS PharmSciTech. 2018 June; Epub ahead of print.
Ellenberger, D.J., Dave A. Miller, Sandra U. Kucera, Robert O. Williams III. “Improved Vemurafenib Dissolution and Pharmacokinetics as an Amorphous Solid Dispersion Produced by KinetiSol® Processing.” AAPS PharmSciTech. 2018 Mar; Epub ahead of print.
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LaFountaine, J.S., Leena Kumari Prasad, Dave A. Miller, James W. McGinity, Robert O.Williams III. “Mucoadhesive Amorphous Solid Dispersions for Sustained Release of Poorly Water Soluble Drugs.” European Journal of Pharmaceutics and Biopharmaceutics. 2017 Apr; 113:157-167. doi: 10.1016/j.ejpb.2016.12.031. Epub 2017 Jan 11.
LaFountaine, J.S., Scott V. Jermain, Leena Kumari Prasad, Chris Brough, Dave A. Miller, Dieter Lubda, James W. McGinity, Robert O. Williams III. “Enabling Thermal Processing of Ritonavir-Polyvinyl Alcohol Amorphous Solid Dispersions by KinetiSol® Dispersing.” European Journal of Pharmaceutics and Biopharmaceutics. 2016 Apr; 101:72-81. doi: 10.1016/j.ejpb.2016.01.018. Epub 2016 Feb 6.
Brough, Chris, Dave A. Miller, Justin M. Keen, Shawn A. Kucera, Dieter Lubda, Robert O. Williams III. “New Use of Polyvinyl Alcohol as a Solubility Enhancing Polymer for Poorly Water-soluble Drug Delivery (Part 1).” AAPS PharmSciTech. 2016 Feb;17(1):167-79. doi: 10.1208/s12249-015-0458-y. Epub 2015 Dec 4.
LaFountaine, Justin S., Leena K. Prasad, Chris Brough, Dave A. Miller, James W. McGinity, Robert O. Williams III. “Thermal Processing of PVP- and HPMC-based Amorphous Solid Dispersions.” AAPS PharmSciTech. 2016 Feb; 17(1): 120–132.
Miller, Dave A., Justin M. Keen, Chris Brough, Daniel J. Ellenberger, Marshall Cisneros, Robert O. Williams III, James W. McGinity. “Bioavailability Enhancement of a BCS IV Compound Via an Amorphous Combination Product Containing Ritonavir.” Journal of Pharmacy and Pharmacology. 2016 May;68(5):678-91. doi: 10.1111/jphp.12478. Epub 2015 Oct 10.
Miller, Dave A. and Justin M. Keen. KinetiSol®-Based Amorphous Solid Dispersions. In: Amorphous Solid Dispersions, Editors: N. Shah, D. Choi, H. Sandhu, H. Chokshi, and W. Malick. Controlled Release Society and Springer Science. New York, NY, USA. In press, (2014).
Bennett, R.C., Chris Brough, Dave A. Miller, K.P. O’Donnell, Justin M. Keen, Justin R. Hughey, Robert O. Williams III, and James W. McGinity. “Preparation of Amorphous Solid Dispersions by Rotary Evaporation and KinetiSol Dispersing: Approaches to Enhance Solubility of a Poorly Water-Soluble Gum Extract.” Drug Development and Industrial Pharmacy: 1-16 (2013).
Keen, Justin M., James W. McGinity, and Robert O. Williams III. “Enhancing Bioavailability through Thermal Processing.” International Journal of Pharmaceutics. vol. 450, pp. 185-196 (2013).
Brough, Chris and Robert O. Williams III. “Amorphous Solid Dispersions and Nano-Crystal Technologies for Poorly Water-Soluble drug delivery.” International Journal of Pharmaceutics. vol. 453, pp. 157-166 (2013).
McGinity, James W., Robert O. Williams III, Justin R. Hughey, James C. DiNunzio, and Dave A. Miller. “KinetiSol®: A Novel Process for the Production of Pharmaceutical Solid Dispersion Systems.” Bulletin Technique Gattefosse. no. 105 (2012): 68-78.
Miller, Dave A., James C. DiNunzio, Justin R. Hughey, Robert O. Williams III, and James W. McGinity. “KinetiSol®: A New Processing Paradigm for Amorphous Solid Dispersion Systems.” Drug Development & Delivery. vol. 12, no. 9, November/December (2012).
Hughey, Justin R., Justin M. Keen, Dave A. Miller, Chris Brough, and James W. McGinity. “Preparation and Characterization of Fusion Processed Solid Dispersions Containing a Viscous Thermally Labile Polymeric Carrier.” International Journal of Pharmaceutics. vol. 438 (2012): 11 – 19.
Hughey, Justin R., Justin M. Keen, Chris Brough, Sophie Saeger, and James W. McGinity. “Thermal Processing of a Poorly Water- Soluble Drug Substance Exhibiting a High Melting Point: The Utility of KinetiSol® Dispersing.” International Journal of Pharmaceutics. vol. 419, no. 1–2 (2011): 222-230.
Hughey, Justin R., James C. DiNunzio, Ryan C. Bennett, Chris Brough, Dave A. Miller, Hua Ma, Robert O. Williams III, and James W. McGinity. “Dissolution Enhancement of a Drug Exhibiting Thermal and Acidic Decomposition Characteristics by Fusion Processing: A Comparative Study of Hot Melt Extrusion and KinetiSol® Dispersing.” AAPS PharmSciTech. vol. 11, no. 2 (2010): 760-774.
DiNunzio, James C., Justin R. Hughey, Chris Brough, Dave A. Miller, Robert O. Williams III, and James W. McGinity. “Production of Advanced Solid Dispersions for Enhanced Bioavailability of Itraconazole Using KinetiSol® Dispersing.” Drug Development and Industrial Pharmacy. vol. 36, no. 9 (2010): 1064-1078.
DiNunzio, James C., Chris Brough, Dave A. Miller, Robert O. Williams III, and James W. McGinity. “Fusion Processing of Itraconazole Solid Dispersions by KinetiSol® Dispersing: A Comparative Study to Hot Melt Extrusion.” Journal of Pharmaceutical Sciences. vol. 99, no. 3 (2010): 1239-1253.
Latest News:
DiNunzio, James C., Chris Brough, Dave A. Miller, Robert O. Williams III, and James W. McGinity. “Applications of KinetiSol® Dispersing for the Production of Plasticizer Free Amorphous Solid Dispersions.” European Journal of Pharmaceutical Sciences. vol. 40, no. 3 (2010): 179-187.
DiNunzio, James C., Chris Brough, Justin R. Hughey, Dave A. Miller, Robert O. Williams III, and James W. McGinity. “Fusion Production of Solid Dispersions Containing a Heat-Sensitive Active Ingredient by Hot Melt Extrusion and KinetiSol® Dispersing.” European Journal of Pharmaceutics and Biopharmaceutics. vol. 74, no. 2 (2010): 340-351.