Publications - DisperSol Technologies

DisperSol News

April 2018

DisperSol Technologies Raising $27 Million and Initiating Phase II trials of DST-0509 in Iron Overload Disorder

November 2017

DisperSol Technologies Announces New R&D Data to Be Presented at 2017 Annual Meeting of AAPS

November 2016

DisperSol Names Dr. Edward M. Rudnic as Chief Executive Officer, RCT Leads $12 Million Funding Round

February 2015

DisperSol Technologies Secures over $10 Million with the Close of Financing Led by Research Corporation Technologies

KinetiSol^® Publications

Ellenberger, D.J., Dave A. Miller, Sandra U. Kucera, Robert O. Williams III. “Generation of a Weakly Acidic Amorphous Solid Dispersion of the Weak Base Ritonavir with Equivalent In Vitro and In Vivo Performance to Norvir Tablet.” AAPS PharmSciTech. 2018 June; Epub ahead of print.

Ellenberger, D.J., Dave A. Miller, Sandra U. Kucera, Robert O. Williams III. “Improved Vemurafenib Dissolution and Pharmacokinetics as an Amorphous Solid Dispersion Produced by KinetiSol® Processing.” AAPS PharmSciTech. 2018 Mar; Epub ahead of print.

Keen, J.M., Justin S. LaFountaine, Justin R. Hughey, Dave A. Miller, James W. McGinity. “Development of Itraconazole Tablets Containing Viscous KinetiSol® Solid Dispersions: In Vitro and In Vivo Analysis in Dogs.” AAPS PharmSciTech. 2017 Nov; doi: 10.1208/s12249-017-0903-1. [Epub ahead of print].

Keen, J.M., Dave A. Miller and Simon Tulloch. “Phase I Trial Results of a Solid Dispersion Formulation of Deferasirox with Enhanced Bioavailability Relative to Exjade® and Jadenu™.“ Blood. 2017; 130:2215.

LaFountaine, J.S., Leena Kumari Prasad, Dave A. Miller, James W. McGinity, Robert O.Williams III. “Mucoadhesive Amorphous Solid Dispersions for Sustained Release of Poorly Water Soluble Drugs.” European Journal of Pharmaceutics and Biopharmaceutics. 2017 Apr; 113:157-167. doi: 10.1016/j.ejpb.2016.12.031. Epub 2017 Jan 11.

LaFountaine, J.S., Scott V. Jermain, Leena Kumari Prasad, Chris Brough, Dave A. Miller, Dieter Lubda, James W. McGinity, Robert O. Williams III. “Enabling Thermal Processing of Ritonavir-Polyvinyl Alcohol Amorphous Solid Dispersions by KinetiSol® Dispersing.” European Journal of Pharmaceutics and Biopharmaceutics. 2016 Apr; 101:72-81. doi: 10.1016/j.ejpb.2016.01.018. Epub 2016 Feb 6.

LaFountaine, J.S., James W. McGinity, Robert O. Williams III. “Challenges and Strategies in Thermal Processing of Amorphous Solid Dispersions: A Review.” AAPS PharmSciTech. 2016 Feb; 17(1):43–55. doi: 10.1208/s12249-015-0393-y. Epub 2015 Aug 26.

Brough, Chris, Dave A. Miller, Justin M. Keen, Shawn A. Kucera, Dieter Lubda, Robert O. Williams III. “New Use of Polyvinyl Alcohol as a Solubility Enhancing Polymer for Poorly Water-soluble Drug Delivery (Part 1).” AAPS PharmSciTech. 2016 Feb;17(1):167-79. doi: 10.1208/s12249-015-0458-y. Epub 2015 Dec 4.

LaFountaine, Justin S., Leena K. Prasad, Chris Brough, Dave A. Miller, James W. McGinity, Robert O. Williams III. “Thermal Processing of PVP- and HPMC-based Amorphous Solid Dispersions.” AAPS PharmSciTech. 2016 Feb; 17(1): 120–132.

Miller, Dave A., Justin M. Keen, Chris Brough, Daniel J. Ellenberger, Marshall Cisneros, Robert O. Williams III, James W. McGinity. “Bioavailability Enhancement of a BCS IV Compound Via an Amorphous Combination Product Containing Ritonavir.” Journal of Pharmacy and Pharmacology. 2016 May;68(5):678-91. doi: 10.1111/jphp.12478. Epub 2015 Oct 10.

Miller, Dave A. and Justin M. Keen. KinetiSol^®-Based Amorphous Solid Dispersions. In: Amorphous Solid Dispersions, Editors: N. Shah, D. Choi, H. Sandhu, H. Chokshi, and W. Malick. Controlled Release Society and Springer Science. New York, NY, USA. In press, (2014).

Bennett, R.C., Chris Brough, Dave A. Miller, K.P. O’Donnell, Justin M. Keen, Justin R. Hughey, Robert O. Williams III, and James W. McGinity. “Preparation of Amorphous Solid Dispersions by Rotary Evaporation and KinetiSol Dispersing: Approaches to Enhance Solubility of a Poorly Water-Soluble Gum Extract.” Drug Development and Industrial Pharmacy: 1-16 (2013).

Keen, Justin M., James W. McGinity, and Robert O. Williams III. “Enhancing Bioavailability through Thermal Processing.” International Journal of Pharmaceutics. vol. 450, pp. 185-196 (2013).

Brough, Chris and Robert O. Williams III. “Amorphous Solid Dispersions and Nano-Crystal Technologies for Poorly Water-Soluble drug delivery.” International Journal of Pharmaceutics. vol. 453, pp. 157-166 (2013).

McGinity, James W., Robert O. Williams III, Justin R. Hughey, James C. DiNunzio, and Dave A. Miller. “KinetiSol^®: A Novel Process for the Production of Pharmaceutical Solid Dispersion Systems.” Bulletin Technique Gattefosse. no. 105 (2012): 68-78.

Miller, Dave A., James C. DiNunzio, Justin R. Hughey, Robert O. Williams III, and James W. McGinity. “KinetiSol^®: A New Processing Paradigm for Amorphous Solid Dispersion Systems.” Drug Development & Delivery. vol. 12, no. 9, November/December (2012).

Hughey, Justin R., Justin M. Keen, Dave A. Miller, Chris Brough, and James W. McGinity. “Preparation and Characterization of Fusion Processed Solid Dispersions Containing a Viscous Thermally Labile Polymeric Carrier.” International Journal of Pharmaceutics. vol. 438 (2012): 11 – 19.

Hughey, Justin R., Justin M. Keen, Chris Brough, Sophie Saeger, and James W. McGinity. “Thermal Processing of a Poorly Water- Soluble Drug Substance Exhibiting a High Melting Point: The Utility of KinetiSol^® Dispersing.” International Journal of Pharmaceutics. vol. 419, no. 1–2 (2011): 222-230.

Hughey, Justin R., James C. DiNunzio, Ryan C. Bennett, Chris Brough, Dave A. Miller, Hua Ma, Robert O. Williams III, and James W. McGinity. “Dissolution Enhancement of a Drug Exhibiting Thermal and Acidic Decomposition Characteristics by Fusion Processing: A Comparative Study of Hot Melt Extrusion and KinetiSol^® Dispersing.” AAPS PharmSciTech. vol. 11, no. 2 (2010): 760-774.

DiNunzio, James C., Justin R. Hughey, Chris Brough, Dave A. Miller, Robert O. Williams III, and James W. McGinity. “Production of Advanced Solid Dispersions for Enhanced Bioavailability of Itraconazole Using KinetiSol^® Dispersing.” Drug Development and Industrial Pharmacy. vol. 36, no. 9 (2010): 1064-1078.

DiNunzio, James C., Chris Brough, Dave A. Miller, Robert O. Williams III, and James W. McGinity. “Fusion Processing of Itraconazole Solid Dispersions by KinetiSol^® Dispersing: A Comparative Study to Hot Melt Extrusion.” Journal of Pharmaceutical Sciences. vol. 99, no. 3 (2010): 1239-1253.